今天是 2021年09月29日 星期三

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导师团队
导师信息
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0755-86585234

xq.lv@siat.ac.cn

深圳市南山区深圳大学城学苑大道1068号

导师信息

  • 阮长顺

    阮长顺

    博士

    研究员

    邮箱 : cs.ruan@siat.ac.cn

简介:

阮长顺,工学博士,中国科学院深圳先进技术研究院研究员,博士生导师,国家自然科学基金委优秀青年基金获得者,聚焦于生物3D打印组织再生与器官重建的新材料、新技术及新策略交叉前沿科学研究,系统性建立了生物打印材料体系的可打印性、力学行为及生物活性等关键因素间相互影响规律,突破了当前挤出型生物3D打印技术的宏微观尺度及精准性,实现了多种复杂组织/器官快速仿生组装与功能重建。入选深圳市高层次留学回国人才计划(2015)、广东省科技创新青年拨尖人才(2015)及中国科学院青年促进创新委员会会员(2019)。先后赴意大利罗马第二大学和香港大学开展访学交流;主持国家自然基金3项(1项青年,2项面上),广东省科技项目3项及深圳市科技创新项目4项;作为骨干参与国家重点研发计划及中国科学院先导A类战略性先导科技器官重建与制造专项等;在生物打印及材料领域发表SCI收录论文50余篇,其中一作或者通讯论文30篇(5篇IF>15,12篇IF>8),包括领域权威期刊:Advanced Functional Materials(IF= 16.836,3篇)、Advanced Science(IF=15.840,2篇)及Biomaterials(IF=10.317)等;研究成果也受到了国内外同行学者的关注(Chem. Rev.,Adv. Mater.,Mater. Sci. Eng. R.等权威期刊引用)及多家科技媒体报道(中国科学报、广东科技报等);申报中国发明专利30余项,国际PCT专利6项,获发明专利授权12项;撰写生物材料领域英文书籍1章节;担任中国医药生物技术协会 3D打印分会第一届委员会委员兼生物材料学组副组长、中国医疗保健国际交流促进会骨科分会委员、中国医学装备协会医用增材制造专业委员会委员及国际华人骨研学会(ICMRS)终身会员;担任生物制造领域国际期刊Bio-Design and Manufacturing 副主编、中国科技卓越期刊 Chinese Chemical Letters 青年编委。




学科类别:


生物医学工程; 生物材料


承担科研项目情况


国家自然基金;国家重点研发计划;广东省科技基金;深圳市科创委基础布局等。


个人主页: http://htod.siat.ac.cn/Team/detail.shtml?id=8&cid=11

研究方向:

生物3D打印;生物材料(高分子或凝胶类);组织再生与修复

主要学术任职:

中国医促会骨科分会生物材料组、中国生物材料协会及中国医药生物技术协会3D打印分会等委员




主要代表论著(通讯或一作,最具代表性 5 篇):

(1)     Qingfei Liang; Fei Gao; Zhiweng Zeng; Jirong Yang; Mingming Wu; Chongjian Gao; Delin Cheng; Haobo Pan*; Wenguang Liu*; Chsangshun Ruan*. Coaxial Scale-up Printing of Diameter-tunable Biohybrid Hydrogel Microtubes with High Strength, Perfusability and Endothelialization. Advanced Functional Materials, 2020. 2001485

(2)     Zifeng Lin; Mingming Wu; Huimin He; Qingfei Liang; Chengshen Hu; Zhiwen Zeng; Delin Cheng; Guocheng Wang; Dafu Chen*; Haobo Pan*; Changshun Ruan*; 3D Printing of Mechanically Stable Calcium-Free Alginate-Based Scaffolds with Tunable Surface Charge to Enable Cell Adhesion and Facile Biofunctionalization, Advanced Functional Materials, 2019, 29(9): 1808439.

(3)     Fei Gao; Ziyang Xu; Qingfei Liang; Haofei Li; Liuqi Peng; Mingming Wu; Xiaoli Zhao; Xu Cui; Changshun Ruan*; Wenguang Liu*; Osteochondral Regeneration with 3D-Printed Biodegradable High-Strength Supramolecular Polymer Reinforced-Gelatin Hydrogel Scaffolds, Advanced Science, 2019, 6(15): 1900867. 

(4)     Xinyun Zhai; Changshun Ruan*; Yufei Ma; Cheng Delin; Mingming Wu; Wenguang Liu; Xiaoli Zhao; Haobo Pan*; William Weijia Lu*; 3D-Bioprinted Osteoblast-Laden Nanocomposite Hydrogel Constructs with Induced Microenvironments Promote Cell Viability, Differentiation, and Osteogenesis both In Vitro and In Vivo, Advanced Science, 2018, 5(3): 1700550.  

(5)     Fei Gao; Ziyang Xu; Qingfei Liang; Bo Liu; Haofei Li; Yuanhao Wu; Yinyu Zhang; Zifeng Lin; Mingming Wu; Changshun Ruan*; Wenguang Liu*; Direct 3D Printing of High Strength Biohybrid Gradient Hydrogel Scaffolds for Efficient Repair of Osteochondral Defect, Advanced Functional Materials, 2018, 28(13): 1706644. 

(6)     Hanhan Xie#; Jundong Shao#; Yufei Ma#; Jiahong Wang; Hao Huang; Na Yang; Huaiyu Wang; Changshun Ruan*; Yanfeng Luo; Qu-Quan Wang; Paul K. Chu; Xue-Feng Yu*; Biodegradable near-infrared-photoresponsive shape memory implants based on black phosphorus nanofillers, Biomaterials, 2018, 164: 11-21.

(7)     Huimin He# Duo Li#, Zifeng Lin, Liuqi Peng, Jirong Yang, Mingming Wu, Delin Cheng, Haobo Pan and Changshun Ruan*; Temperature-programmable and Enzymatically Solidifiable Gelatinbased Bioinks Enable Facile Extrusion Bioprinting. Biofabrication, 2020, 12: 045003.

(8)     Duo Li #, Baochun Guo #, Qingfei Liang, Yunhui Liu, Lu Zhang, Nan Hu *, Xinzhou Zhang, Fan Yang*, Changshun Ruan *.Tissue-engineered Parathyroid Gland and Its Regulatory Secretion of Parathyroid Hormone. Journal of Tissue Engineering and Regenerative Medicine, 2020, doi: 10.1002/term.3080.

(9)     Moyuan Deng,#,* Jiulin Tan#, Chengshen Hu, Tianyong Hou, Wei Peng, Juan Liu, Bo Yu,Qijie Dai, Jiangling Zhou, Yusheng Yang, Rui Dong, Changshun Ruan,* Shiwu Dong,*and Jianzhong Xu*.Modification of PLGA Scaffold by MSC-Derived Extracellular Matrix Combats Macrophage Inflammation to Initiate Bone Regeneration via TGF-β-Induced Protein. Advanced Healthcare Materials, 2020, 2020, 9(13): 200353.

(10) Fei Gao; Changshun Ruan*; Wenguang Liu*; High-strength hydrogel-based bioinks, Materials Chemistry Frontiers, 2019, 3(9): 1736-1746.  

(11) Jinghua Li#; Yun Liu#; Xiaonan Li; Gaofeng Liang; Changshun Ruan*; Kaiyong Cai*; ROS self-generation and hypoxia self-enhanced biodegradable magnetic nanotheranostics for targeted tumor therapy, Nanoscale Horizons, 2020, 5(2): 350-358.  

(12) Yufei Ma#; Nan Hu#; Juan Liu#; Xinyun Zhai; Mingming Wu; Chengshen Hu; Long Li; Yuxiao Lai; Haobo Pan; William Weijia Lu; Xinzhou Zhang; Yanfeng Luo*; Changshun Ruan*; Three-Dimensional Printing of Biodegradable Piperazine-Based Polyurethane-Urea Scaffolds with Enhanced Osteogenesis for Bone Regeneration, ACS Applied Materials & Interfaces, 2019, 11(9): 9415-9424.  

(13) Delin Cheng#; Qingfei Liang#; Yonggang Li; Jiahui Fan; Guocheng Wang; Haobo Pan; Changshun Ruan*; Strontium incorporation improves the bone-forming ability of scaffolds derived from porcine bone, Colloids and Surfaces B: Biointerfaces, 2018, 162: 279-287.   

(14) Bo Li#; Changshun Ruan#; Yufei Ma; Zhifeng Huang; Zhenfei Huang; Gang Zhou; Jing Zhang; Hai Wang*; Zhihong Wu*; Guixing Qiu; Fabrication of Vascularized Bone Flaps with Sustained Release of Recombinant Human Bone Morphogenetic Protein-2 and Arteriovenous Bundle, Tissue Engineering - Part A., 2018, 24(17-18): 1413-1422.   

(15) Xinyun Zhai; Chunyong Hou; Haobo Pan; William Weijia Lu; Wenguang Liu*; Changshun Ruan*; Nanoclay Incorporated Polyethylene-Glycol Nanocomposite Hydrogels for Stimulating In Vitro and In Vivo Osteogenesis, Journal of Biomedical Nanotechnology, 2018, 14(4): 662-674. 

(16) Xinyun Zhai; Yufei Ma; Chunyong Hou,; Fei Gao; Yinyu Zhang; Changshun Ruan*; Haobo Pan; William Weijia Lu*; Wenguang Liu*; 3D-Printed High Strength Bioactive Supramolecular Polymer/Clay Nanocomposite Hydrogel Scaffold for Bone Regeneration, ACS Biomaterials-Science & Engineering, 2017, 3(6): 1109-1118. 

(17) Xu Cui; Chengcheng Huang; Meng Zhang; Changshun Ruan*; Songlin Peng; Li Li; Wenlong Liu; Ting Wang; Bing Li; Wenhai Huang; Mohamed N. Rahaman; William W. Lu; Haobo Pan*; Enhanced osteointegration of poly(methylmethacrylate) bone cements by incorporating strontium-containing borate bioactive glass, Journal of the Royal Society Interface, 2017, 14(131): 20161057. 

(18) Yongxiang Luo*; Guilin Luo; Michael Gelinsky; Peng Huang*; Changshun Ruan*; 3D bioprinting scaffold using alginate/polyvinyl alcohol bioinks, Materials Letters, 2017, 189: 295-298.

(19) Guilin Luo#; Yufei Ma#; Xu Cui; Lixin Jiang; Mingming Wu; Yang Hu; Yanfeng Luo; Haobo Pan; Changshun Ruan*; 13-93 bioactive glass/alginate composite scaffolds 3D printed under mild conditions for bone regeneration, RSC Advances, 2017, 7(20): 11880-11889.

(20)  Juan Xing; Yufei Ma; Manping Lin; Yuanliang Wang; Haobo Pan; Changshun Ruan*;  Yanfeng Luo*; Stretching-induced nanostructures on shape memory polyurethane films and their regulation to osteoblasts morphology, Colloids and Surfaces B: Biointerfaces, 2016, 146: 431-441.



地址:深圳市南山区深圳大学城学苑大道1068号 邮编:518055 电子邮箱:xq.lv@siat.ac.cn

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