导师信息
-
崔旭
博士
副研究员
邮箱 : xu.cui@siat.ac.cn
简介:
工学博士，副研究员/副教授，医疗器械高级工程师，博士生导师，“鹏城孔雀计划”特聘人才，入选2023全球前2％顶尖科学家榜单,2024年入选全球“终身科学影响力榜单"。现任中国科学院深圳先进技术研究院医药所人体组织与器官退行性研究中心微环境调控组织再生及其产业转化课题组PI，深圳理工大学药学院科研副教授，兼任深圳市中科海世御生物科技有限公司研发总监。一直从事于骨与创伤的修复重建、骨与关节病发病机理及相关骨组织再生机制研究工作。针对生物活性玻璃的基础理论研究，发现通过设计玻璃网络结构中的硼/硅比以及其它元素的引入量，可以调控硼硅酸盐生物活性玻璃的反应活性、降解、离子析出和碱性微环境形成。并发现离子和碱性微环境是构建成骨的必然选择，在成骨的过程中必然存在离子和碱性微环境的综合作用，能改善和调节骨稳态失衡。先后开发了生物活性玻璃基的多孔支架、复合水凝胶、药物载体、骨水泥、纤维等，用于骨、软骨和皮肤创伤等的修复重建。目前，相关研究已在Adv Sci、Bio Mater、ACS Appl. Mater. Interfaces、Mater. Sci. Eng. C等期刊发表相关论文20余篇，申请国家发明专利20余项，其中已获得授权专利8项。目前主持国家自然科学基金委项目2项，广东省自然科学基金项目1项；并参与了科技部重点研发计划、国家自然科学基金委项目、中国科学院前沿和先导项目、广东省自然科学基金项目等多项省部级项目。负责并参与了6种骨和创伤医疗三类医疗器械、3种二类和一类器械等的产业研发，目前1种三类器械已经开展临床试验，1种二类器械完成了临床资料评价。在国际和国内学士会议报告20余次。同时担任“Advanced Science和Journal of Tissue Engineering and Regenerative Medicine”等知名杂志的审稿人。
个人主页:
研究方向:
骨组织工程；骨免疫学；生物活性玻璃；创伤敷料；海洋生物材料
主要学术任职:
国家自然科学基金委项目评审专家、广东省科技厅项目评审专家、深圳市科技项目评审专家、深圳市医疗器械行业评审专家、骨水泥与可注射材料专业委员会委员、中国生物材料学会生物陶瓷分会委员、中国医促会骨科生物材料学部委员
学科类别：
生物医学工程; 生物材料
承担科研项目情况：
国家科技部重点研发计划；国家自然自然科学基金；广东省自然科学基金；深圳市科创委相关项目。
主要代表论著（通讯或一作，最具代表性 5 篇）:
1. Xu Cui#, Chengcheng Huang#, Zhizhen Chen#, Meng Zhang, Chunyu Liu, Kun Su, Jianyun Wang, Li Li, Renxian Wang, Bing Li, Dafu Chen, Changshun Ruan, Deping Wang, William W. Lu, Haobo Pan*. Hyaluronic acid facilitates bone repair effects of calcium phosphate cement by accelerating osteogenic expression. Bioactive Materials, 2021, 6, 3801-3811.
2. Zhangfan Wu, Ziyang Lin, Aihua Yao, Song Ye, Haobo Pan, Xu Cui*, Deping Wang*. Influence of particle size distribution on the rheological properties and mathematical model fitting of injectable borosilicate bioactive glass bone cement. Ceramics International, 2020, 46 (15): 24395-22406.
3. Xu Cui#, Yadong Zhang#, Jianyun Wang#, Chengcheng Huang, Yudong Wang, Hongsheng Yang, Wenlong Liu, Ting Wang, Deping Wang, Guocheng Wang, Changshun Ruan, Dafu Chen*, William W. Lu, Wenhai Huang, Mohamed N. Rahaman*, Haobo Pan*. Strontium Modulates Osteogenic Activity of Bone Cement Composed of Bioactive Borosilicate Glass Particles by Activating Wnt/β-catenin signaling pathway. Bioactive Materials, 2020, 5, 334-347.
4. Xu Cui, Chengcheng Huang, Meng Zhang, Changshun Ruan*, Songlin Peng, Li Li, Wenlong Liu, Ting Wang, Bing Li, Wenhai Huang, Mohamed N. Rahaman, William W Lu, Haobo Pan*. Enhanced osteointegration of poly(methylmethacrylate) bone cements by incorporating strontium-containing borate bioactive glass. Journal of the Royal Society Interface, 2017, 14(131), 20161057.
5. Xu Cui, Wenhai Huang, Yadong Zhang*, Chengcheng Huang, Zunxiong Yu, Lei Wang, Wenlong Liu, Ting Wang, Jie Zhou, Hui Wang, Nai Zhou, Deping Wang, Haobo Pan*, Mohamed N. Rahaman*. Evaluation of an injectable bioactive borate glass cement to heal bone defects in a rabbit femoral condyle model. Materials Science and Engineering: C, 2017, 73, 585-595.
6. Wenlong Liu, Xiuli Dan, William W. Lu, Xiaoli Zhao, Changshun Ruan, Ting Wang, Xu Cui, Xinyun Zhai, Yufei Ma, Deping Wang, Wenhai Huang, and Haobo Pan* Spatial Distribution of Biomaterial Microenvironment pH and Its Modulatory Effect on Osteoclasts at the Early Stage of Bone Defect Regeneration. ACS Applied Materials & Interfaces, 2019, DOI: 10.1021/acsami.8b20580.
7. Tiancheng Lv, Wei Liang, Li Li, Xu Cui, Xiaomou Wei, Haobo Pan, Bing Li*. Novel calcitonin gene‐related peptide/chitosan‐strontium‐calcium phosphate cement: Enhanced proliferation of human umbilical vein endothelial cells in vitro. Journal of Biomedical Materials Research Part B: Applied Biomaterials, 2018, DOI: 10.1002/jbm.b.34091.
8. Li Li, Xiaozhong Peng, Yongbao Qin, Renchong Wang, Jingli Tang, Xu Cui, Ting Wang, Wenlong Liu, Haobo Pan*, Bing Lib*. Acceleration of bone regeneration by activating Wnt/β-catenin signalling pathway via lithium released from lithium chloride/calcium phosphate cement in osteoporosis. Scientific Reports, 2017, 7, 45204.
9. Guilin Luo, Yufei Ma, Xu Cui, Lixin Jiang, Mingming Wu, Yang Hu, Yanfeng Luo, Haobo Pan, Changshun Ruan*. 13-93 bioactive glass/alginate composite scaffolds 3D printed under mild conditions for bone regeneration. RSC Advances, 2017, 7, 11880-11889.
10. Li Li, Renchong Wang, Baichuan Li, Wei Liang, Haobo Pan, Xu Cui, Jingli Tang, Bing Li* . Lithium doped calcium phosphate cement maintains physical mechanical properties and promotes osteoblast proliferation and differentiation. Journal of Biomedical Materials Research Part B: Applied Biomaterials, 2016.03.20.
11. Wei Liang, Zhongfei Tang, Xiaomou Wei, Bing Li*, Li Li, Xu Cui, Haobo Pan. Enhanced proliferation and differentiation effects of a CGRP- and Sr-enriched calcium phosphate cement on bone mesenchymal stem cells. Journal of Applied Biomaterials & Functional Materials, 2016, 14(4), 431-440.
12. Xu Cui#, Yadong Zhang#, Shichang Zhao, Hui Wang, Haobo Pan*, Mohamed N. Rahaman*, Wenhai Huang*, Changqing Zhang. An injectable borate bioactive glass cement for bone repair: Preparation, bioactivity and setting mechanism. Journal of Non-Crystalline Solids, 2016, 432, 150-157.
13. Hui Wang, Shichang Zhao, Jie Zhou, Kaiping Zhu, Xu Cui, Wenhai Huang, Mohamed N. Rahaman*, Changqing Zhang*, Deping Wang*. Biocompatibility and osteogenic capacity of borosilicate bioactive glass scaffolds loaded with Fe3O4 magnetic nanoparticles. Journal of Materials Chemistry B, 2015, 21, 4377-4387.
14. Hui Wang, Shichang Zhao, Wei Xiao, Xu Cui, Wenhai Huang, Mohamed N. Rahaman*, Changqing Zhang*, Deping Wang*. Three-dimensional zinc incorporated borosilicate bioactive glass scaffolds for rodent critical-sized calvarial defects repair and regeneration. Colloids and Surfaces B: Biointerfaces, 130, 149-156, 2015.
15. Hui Wang, Shichang Zhao, Xu Cui, Yangyi Pan, Wenhai Huang, Song Ye, Shihua Luo, Mohamed N. Rahaman, Changqing Zhang, Deping Wang. Evaluation of three-dimensional silver-doped borate bioactive glass scaffolds for bone repair: Biodegradability, biocompatibility, and antibacterial activity. Journal of Materials Research, 2015, 30(18), 2722-2735.
16. Yadong Zhang#, Xu Cui#, Shichang Zhao, Hui Wang, Mohamed N. Rahaman, Wenhai Huang, Changqing Zhang. Evaluation of novel injectable strontium-containing borate bioactive glass cement with desirable workability and enhanced osseointegration properties in a critical-size rabbit femoral condyle defect model. ACS Applied Materials & Interfaces, 2015, 7(4), 2393-2403. (Joint first authors)
17. Xu Cui, Cunju Zhao, Yifei Gu, Le Li, Hui Wang, Wenhai Huang*, Nai Zhou, Deping Wang, Yi Zhu, Jun Xu, Shihua Luo, Changqing Zhang, Mohamed N. Rahaman*. A novel injectable borate bioactive glass cement for local delivery of vancomycin to cure osteomyelitis and regenerate bone. Journal of Materials Science: Materials in Medicine, 2014, 25(3), 733-745.
18. Hao Ding, Cun-Ju Zhao, Xu Cui, Yi-Fei Gu,Wei-Tao Jia, Mohamed N. Rahaman, Yang Wang, Wen-Hai Huang*,Chang-Qing Zhang*. A Novel Injectable Borate Bioactive Glass Cement as an Antibiotic Delivery Vehicle for Treating Osteomyelitis. Plos one, 2014, 9(10), 1-9.
19. Xu Cui, Yifei Gu, Le Li, Hui Wang, Zhongping Xie, Shihua Luo, Nai Zhou, Wenhai Huang*, Mohamed N. Rahaman. In vitro bioactivity, cytocompatibility, and antibiotic release profile of gentamicin sulfate-loaded borate bioactive glass/chitosan composites. Journal of Materials Science: Materials in Medicine, 2013, 24(10), 2391-2403.
20. Zongping Xie, Xu Cui, Cunju Zhao, Wenhai Huang, Jianqiang Wang, Changqing Zhang*. Gentamicin-Loaded Borate Bioactive Glass Eradicates Osteomyelitis Due to Escherichia coli in a Rabbit Model. Antimicrob. Agents Chemother, 2013, 57(7), 3293-3298.