导师信息

• 

  王崇元

  博士

  研究员/副教授

  邮箱 : cy.wang@siat.ac.cn

简介:

   中国科学院深圳先进技术研究院研究员/博士生导师，中科院级人才，获得中科院、国家自然科学基金面上项目、广东省自然科学基金等资助。曾在美国纪念斯隆凯特琳癌症中心做博士后研究并晋升为研究科学家（Senior Research Scientist）。曾获得MSK Postdoc Researcher Award、中科院院长奖等奖项。

   长期致力于跨膜蛋白的结构与功能研究，包括离子通道、膜受体与转运蛋白的三维结构表征、分子机制解析与结构药理学研究。近年来， 以通讯或第一作者（含共同）在 Nature、Science Advances、Nature Communications、eLife等期刊发表论文多篇，在离子通道的结构与门控机制方面取得一系列创新性成果。

个人主页:

研究方向:

1. 重大疾病相关的膜蛋白的结构解析及分子机制研究； 2. 免疫相关受体与配体识别机制的研究； 3. 生物活性分子的筛选及优化。

主要学术任职:

目前担任Nature Communication 等期刊的审稿人、 以及美国生物物理学会、美国生理学会、纽约科学院等学术组织的会员。

学科分类:

分子生物学；结构生物学；生物物理学

主要代表论著（通讯或一作，最具代表性 5 篇）:

(1) Chongyuan Wang*, Maya M. Polovitskaya*, Bryce D. Delgado, Thomas J. Jentsch and Stephen Barstow Long. “Gating mechanism of the proton-activated chloride channel.” Science Advances 8.5 (2022): eabm3942. (2) Chongyuan Wang, Agata Jacewicz, Bryce D. Delgado, Rozbeh Baradaran and Stephen B. Long. “Structures reveal gating of mitochondrial Ca2+ uniporter by MICU1-MICU2.” eLife, 9 (2020): e59991.

(3) Chongyuan Wang*, Rozbeh Baradaran* and Stephen B. Long. “Structure and reconstitution of a MCU-EMRE mitochondrial Ca2+ uniporter complex.” Journal of Molecular Biology, 432, no. 20 (2020): 5632-5648.

(4) Rozbeh Baradaran*, Chongyuan Wang*, Andrew F. Siliciano, and Stephen B. Long."Cryo-EM structures of fungal and metazoan mitochondrial calcium uniporters." Nature, 559, no. 7715 (2018): 580-584. (* equal contribution) F1000Prime recommended

(5) Chongyuan Wang, Yuwei Zhu, Hongyu Bao, Yiyang Jiang, Chao Xu, Jihui Wu, and Yunyu Shi. "A novel RNA-binding mode of the YTH domain reveals the mechanism for recognition of determinant of selective removal by Mmi1." Nucleic Acids Research, 44, no. 2 (2016): 969-982.

(6) Chongyuan Wang, Yuwei Zhu, Tamar B. Caceres, Lei Liu, Junhui Peng, Junchen Wang, Jiajing Chen et al. "Structural determinants for the strict monomethylation activity by trypanosoma brucei protein arginine methyltransferase 7." Structure, 22, no. 5 (2014): 756-768.

(7) Chongyuan Wang*, Yuwei Zhu*, Jiajia Chen, Xu Li, Junhui Peng, Jiajing Chen, Yang Zou et al. "Crystal structure of arginine methyltransferase 6 from Trypanosoma brucei." PLoS one, 9, no. 2

(8) Mengqi Lv, Chongyuan Wang, Fudong Li, Junhui Peng, Bin Wen, Qingguo Gong, Yunyu Shi, and Yajun Tang. "Structural insights into the recognition of phosphorylated FUNDC1 by LC3B in mitophagy." Protein & cell, 8, no. 1 (2017): 25-38.

(9) Ning Jia, Charlie Mo, Chongyuan Wang, Edward T. Eng, Luciano A. Marraffini, and Dinshaw J. Patel. "Type III-A CRISPR-Cas Csm complexes: assembly, periodic RNA cleavage, DNase activity regulation, and autoimmunity." Molecular cell, 73, no. 2 (2019): 264-277.

(10) Juncheng Wang, S. Catania, Chongyuan Wang, MJ. de la Cruz, Beiduo Rao, HD. Madhani & DJ. Patel. (2022). Structural insights into DNMT5-mediated ATP-dependent high-fidelity epigenome maintenance. Molecular Cell, 82(6), 1186-1198.