导师信息
-
王怀雨
博士
研究员
邮箱 : hy.wang1@siat.ac.cn
简介:
中国科学院深圳先进技术研究院研究员/博导，国家级青年人才/中国科学院青年创新促进会优秀会员，连续两年入选“全球前2%顶尖科学家榜单”，Plasma Based Ion Implantation & Deposition International Committee Member/Smart Materials in Medicine杂志副主编/中国生物材料学会康复器械与生物材料分会副主任委员/中国生物材料学会青年委员会委员。2004年本科毕业于北京大学药学院，2009年博士毕业于中国科学院理化技术研究所，2007-2009年以及2009-2013年分别以研究助理和博士后身份在香港城市大学进行研究工作，主要研究方向为生物材料的表/界面功能构建。先后承担国家自然科学基金、国家重点研发计划课题、中国科学院STS区域重点、深港创新圈联合资助等项目。共发表SCI论文120余篇，引用11400余次；一作/通讯作者论文60余篇，其中逾30余篇发表在Nature Communications、The Innovation、Advanced Materials、Angewandte Chemie International Edition、Advanced Functional Materials、ACS Nano、Nano Today、Advanced Science、Biomaterials、Bioactive Materials、Materials Horizons、Small、Composites Part B: Engineering、 ACS Applied Materials & Interfaces、Acta Biomaterialia等权威刊物。
个人主页:
研究方向:
骨科植入材料；表/界面功能调控；组织修复与再生
主要学术任职:
Plasma Based Ion Implantation & Deposition International Committee Member; Smart Materials in Medicine杂志副主编；中国生物材料学会康复器械与生物材料分会副主任委员；中国生物材料学会青年委员会委员
学科类别：
生物医学工程; 生物材料
主要代表论著（通讯或一作，最具代表性 5 篇）:
1. #Lei Yu, #Wenming Li, #Peng Yang, Wei Zhang, Huaqiang Tao, Gaoran Ge, Huilin Yang, *Jiaxiang Bai, *Huaiyu Wang(Corresponding author), *Dechun Geng. Osteoblastic MicroRNAs in Skeletal Disease: Biological Functions and Therapeutic Implications. Engineered Regeneration, in press.
2. #Yanyan Zheng, #Ang Gao, #Jiaxiang Bai, Qing Liao, Yuzheng Wu, Wei Zhang, Min Guan, *Liping Tong, *Dechun Geng, Xin Zhao, Paul K. Chu, *Huaiyu Wang(Corresponding author). A Programmed Surface on Polyetheretherketone for Sequentially Dictating Osteoimmunomodulation and Bone Regeneration to Achieve Ameliorative Osseointegration under Osteoporotic Conditions. Bioactive Materials, 14, 364-376, 2022.
3. Junfeng Chen, Lingxia Xie, Qingdong Ruan, Ang Gao, Qing Liao, Shi Mo, Yuanliang Lv, *Liping Tong, *Huaiyu Wang(Corresponding author), Paul K. Chu, *Xiaoming Li. Diamond-like Carbon Coating and Surface Grafting of Osteoprotegerin and Alendronate on Polyetheretherketone to Ameliorate the Mechanical Performance and Osseointegration Simultaneously. Composites Part B, 236, 109815, 2022.
4. #Yuzheng Wu, #Qingdong Ruan, Chao Huang, Qing Liao , Liangliang Liu, Pei Liu, Shi Mo, *Guomin Wang, *Huaiyu Wang(Corresponding author), *Paul K. Chu. Balancing the Biocompatibility and Bacterial Resistance of Polypyrrole by Optimized Silver Incorporation. Materials Science & Engineering C, in press.
5. #Meng Li, #Jiaxiang Bai, #Huaqiang Tao, Li Hao, Weiling Yin, Xiaoxue Ren, Ang Gao, Ning Li, Miao Wang, Shiyuan Fang, Yaozeng Xu, Liang Chen, Huilin Yang, *Huaiyu Wang(Corresponding author), *Guoqing Pan, *Dechun Geng. Rational Integration of Defense and Repair Synergy on PEEK Osteoimplants via Biomimetic Peptide Clicking Strategy. Bioactive Materials, 8, pp 309-324, 2022.
6. #Yuzheng Wu, #Qing Liao, #Lie Wu, Yongxiang Luo, Wei Zhang, Min Guan, Haobo Pan, *Liping Tong, *Paul K. Chu, *Huaiyu Wang(Corresponding author). ZnL2-BPs Integrated Bone Scaffold under Sequential Photothermal Mediation: A Win−Win Strategy Delivering Antibacterial Therapy and Fostering Osteogenesis Thereafter. ACS Nano, 15, 17854-17869, 2021.
7. #Lingxia Xie, #Guomin Wang, Yuzheng Wu, Qing Liao, Shi Mo, Xiaoxue Ren, Liping Tong, Wei Zhang, Min Guan, Haobo Pan, Paul K. Chu, *Huaiyu Wang(Corresponding author). Programmed Surface on Poly(Aryl-Ether-Ether-Ketone) Initiating Immune Mediation and Fulfilling Bone Regeneration Sequentially. The Innovation, 2, 100148, 2021.
8. #Shi Mo, #Feilong Zhao, #Ang Gao, Yuzheng Wu, Qing Liao, Lingxia Xie, *Liping Tong, *Paul K. Chu, *Huaiyu Wang(Corresponding author). Simultaneous Application of Diamond-like Carbon Coating and Surface Amination on Polyether Ether Ketone: Towards Superior Mechanical Performance and Osseointegration. Smart Materials in Medicine, 2, pp 219-228, 2021.
9. Nan Hu, Lingxia Xie, Qing Liao, Ang Gao, Yanyan Zheng, Haobo Pan, *Liping Tong, *Dazhi Yang, Nong Gao, Marco J. Starink, Paul K. Chu, *Huaiyu Wang(Corresponding author). A More Defective Substrate Leads to a Less Defective Passive Layer: Enhancing the Mechanical Strength, Corrosion Resistance and Anti-inflammatory Response of the Low-Modulus Ti-45Nb Alloy by Grain Refinement. Acta Biomaterialia, 126, pp 524-536, 2021.
10. Saud Khalid, Ang Gao, *Guomin Wang, Paul K. Chu, *Huaiyu Wang(Corresponding author). Tuning Surface Topographies on Biomaterials to Control Bacterial Infection. Biomaterials Science, 8, pp 6840-6857, 2020.
11. #Zhibin Li, #Guanghong Luo, #Weiping Hu, Jianlan Hua, Shengyong Geng, Paul K. Chu, *Jing Zhang, *Huaiyu Wang(Corresponding author), *Xuefeng Yu. Mediated Drug Release from Nano-Vehicles by Black Phosphorus Quantum Dots for Efficient Therapy of Chronic Obstructive Pulmonary Disease. Angewandte Chemie International Edition, 59, pp 20568-20576, 2020.
12. #Jiaxiang Bai, #Huaiyu Wang (Co-first author), #Hao Chen, Gaoran Ge, Miao Wang, Ang Gao, Liping Tong, Yaozeng Xu, Huiling Yang, *Guoqing Pan, *Paul K. Chu, *Dechun Geng. Biomimetic Osteogenic Peptide with Mussel Adhesion and Osteoimmunomodulatory Functions to Ameliorate Interfacial Osseointegration under Chronic Inflammation. Biomaterials, 255, 120197, 2020.
13. #Nan Hu, #Yuzheng Wu, Lingxia Xie, Shahir Mohd Yusuf, Nong Gao, Marco J. Starink, *Liping Tong, *Paul K. Chu, *Huaiyu Wang(Corresponding author). Enhanced Interfacial Adhesion and Osseointegration of Anodic TiO2 Nanotube Arrays on Ultra-Fine-Grained Titanium and Underlying Mechanisms. Acta Biomaterialia, 106, pp360-375, 2020.
14. Ang Gao, Qing Liao, Lingxia Xie, Guomin Wang, Wei Zhang, Yuzheng Wu, Penghui Li, Min Guan, Haobo Pan, *Liping Tong, *Paul K. Chu, *Huaiyu Wang(Corresponding author). Tuning the Surface Immunomodulatory Functions of Polyetheretherketone for Enhanced Osseointegration. Biomaterials, 230, 119642, 2020.
15. Guomin Wang, Wenjuan Jiang, Shi Mo, Lingxia Xie, Qing Liao, Liangsheng Hu, Qingdong Ruan, Kaiwei Tang, Babak Mehrjou, Mengting Liu, Liping Tong, *Huaiyu Wang(Corresponding author), *Jie Zhuang, *Guosong Wu, *Paul K. Chu. Nonleaching Antibacterial Concept Demonstrated by In Situ Construction of 2D Nanoflakes on Magnesium. Advanced Science, 7, 1902089, 2020.
16. Penghui Li, Jin Chen, *Paul K. Chu, *Huaiyu Wang(Corresponding author). Fundamentals and Applications of Surface-enhanced Raman Spectroscopy (SERS) Based Biosensor. Current Opinion in Biomedical Engineering, 13, pp 51-59, 2020.
17. *Wei Zhang, Jun Liu, Kun Yang, Wei Qu, Ke Liu, Na Liu, Bin Gu, Nan Hu, Junhui Ji, Paul K. Chu, *Huaiyu Wang(Corresponding author). Unique Role of Arginine in Positively-Charged Surface for Promotion of Antibacterial and Osteogenetic Capabilities. Advanced Materials Interfaces, 6, 1901414, 2019.
18. Nan Hu, Tao Hu, Ang Gao, Nong Gao, Marco J. Starink, Ying Chen, Wanting Sun, Qing Liao, *Liping Tong, *Xiaochang Xu, Paul K. Chu, *Huaiyu Wang(Corresponding author). Homogeneous Anodic TiO2 Nanotube Layers on Ti-6Al-4V Alloy with Improved Adhesion Strength and Corrosion Resistance. Advanced Materials Interfaces, 6, 1801964, 2019.
19. #Zhibin Li, #Lie Wu, *Huaiyu Wang(Corresponding author), Wenhua Zhou, Hanxia Liu, Haodong Cui, Penghui Li, *Paul K. Chu, *Xuefeng Yu. Synergistic Antibacterial Activity of Black Phosphorus Nanosheets Modified with Titanium Aminobenzenesulfanato Complexes. ACS Applied Nano Materials, 2, pp 1202-1209, 2019.
20. Liping Tong, Qing Liao, Yuetao Zhao, Hao Huang, Ang Gao, Wei Zhang, Xiaoyong Gao, Wei Wei, Min Guan, Paul K. Chu, *Huaiyu Wang(Corresponding author). Near-Infrared Light Control of Bone Regeneration with Biodegradable Photothermal Osteoimplant. Biomaterials, 193, pp 1-11, 2019.
21. #Guomin Wang, #Hongqing Feng, Liangsheng Hu, Weihong Jin, Qi Hao, Ang Gao, Xiang Peng, Wan Li, Kwok-Yin Wong, *Huaiyu Wang(Corresponding author), *Zhou Li, *Paul K. Chu. An Antibacterial Platform Based on Capacitive Carbon-Doped TiO2 Nanotubes after Direct or Alternating Current Charging. Nature Communications, 9, 2055, 2018.
22. #Yuchang Weng, #Hanxia Liu, Shunping Ji, Qian Huang, Hao Wu, Zhibin Li, *Zhongzhen Wu, *Huaiyu Wang(Corresponding author), Liping Tong, Ricky K.Y. Fu, *Paul K. Chu, Feng Pan. A Promising Orthopedic Implant Material with Enhanced Osteogenic and Antibacterial Activity: Al2O3-Coated Aluminum Alloy. Applied Surface Science, 457, pp 1025-1034, 2018.
23. Jundong Shao, Changshun Ruan, Hanhan Xie, Zhibin Li, *Huaiyu Wang(Corresponding author), Paul K. Chu, *Xuefeng Yu. Black-Phosphorus-Incorporated Hydrogel as a Sprayable and Biodegradable Photothermal Platform for Postsurgical Treatment of Cancer. Advanced Science, 5, 1700848, 2018.
24. Huaiyu Wang, *Xuefeng Yu. Few-Layered Black Phosphorus: From Fabrication and Customization to Biomedical Applications. Small, 14, 1702830, 2018.
25. #Jundong Shao, #Hanhan Xie, *Huaiyu Wang(Corresponding author), Wenhua Zhou, Qian Luo, *Xuefeng Yu, *Paul K. Chu. 2D Material-Based Nanofibrous Membrane for Photothermal Cancer Therapy. ACS Applied Materials & Interfaces, 10, pp 1155-1163, 2018.
26. Ang Gao, Ruiqiang Hang, Wan Li, Wei Zhang, Penghui Li, Guomin Wang, Long Bai, Xuefeng Yu, *Huaiyu Wang(Corresponding author), *Liping Tong, *Paul K. Chu. Linker-free Covalent Immobilization of Heparin, SDF-1α, and CD47 on PTFE Surface for Antithrombogenicity, Endothelialization and Anti-Inflammation. Biomaterials, 140, pp 201-211, 2017.
27. Zhibin Li, Jundong Shao, Qian Luo, *Xuefeng Yu, Hanhan Xie, Haidi Fu, Siying Tang, *Huaiyu Wang(Corresponding author), Guangli Han, *Paul K. Chu. Cell-Borne 2D Nanomaterials for Efficient Cancer Targeting and Photothermal Therapy. Biomaterials, 133, pp 37-48, 2017.
28. Zhengbo Sun, Yuetao Zhao, Zhibin Li, Haodong Cui, Yayan Zhou, Weihao Li, Wei Tao, *Han Zhang, *Huaiyu Wang(Corresponding author), Paul K. Chu, *Xuefeng Yu. TiL4-Coordinated Black Phosphorus Quantum Dots as an Efficient Contrast Agent for In Vivo Photoacoustic Imaging of Cancer. Small, 13, 1602896, 2017.
29. Yuetao Zhao, *Huaiyu Wang(Corresponding author), Hao Huang, Quanlan Xiao, Yanhua Xu, Zhinan Guo, Hanhan Xie, Jundong Shao, Zhengbo Sun, Weijia Han, *Xuefeng Yu, Penghui Li, *Paul K. Chu. Surface Coordination of Black Phosphorus for Robust Air and Water Stability. Angewandte Chemie International Edition, 55, pp 5003-5007, 2016.
30. Yuetao Zhao, Liping Tong, Yong Li, Haobo Pan, Wei Zhang, Min Guan, Weihao Li, Yixin Chen, Qing Li, Zhongjun Li, *Huaiyu Wang(Corresponding author), *Xuefeng Yu, *Paul K. Chu. Lactose-Functionalized Gold Nanorods for Sensitive and Rapid Serological Diagnosis of Cancer. ACS Applied Materials & Interfaces, 8, pp 5813-5820, 2016.
31. #Zhibin Li, #Siying Tang, #Beike Wang, Yong Li, Hao Huang, *Huaiyu Wang(Corresponding author), Penghui Li, *Chengzhang Li, *Paul K. Chu, Xuefeng Yu. Metabolizable Small Gold Nanorods: Size-Dependent Cytotoxicity, Cell Uptake and In Vivo Biodistribution. ACS Biomaterials Science & Engineering, 2, pp 789-797, 2016.
32. #Liping Tong, #Wenhua Zhou, Yuetao Zhao, Xuefeng Yu, *Huaiyu Wang(Corresponding author), *Paul K. Chu. Enhanced Cytocompatibility and Reduced Genotoxicity of Polydimethylsiloxane Modified by Plasma Immersion Ion Implantation. Colloids and Surfaces B: Biointerfaces, 148, pp 139-146, 2016.