导师信息

• 

  阮长顺

  博士

  研究员

  邮箱 : cs.ruan@siat.ac.cn

简介:

  中国科学院深圳先进技术研究院研究员，博士生导师，国家级青年人才，聚焦于生物3D打印组织再生与器官重建的新材料、新技术及新策略交叉前沿科学研究，系统性建立生物打印材料体系的可打印性、力学行为及生物活性等关键因素间相互影响规律，突破当前挤出型生物3D打印技术的宏微观尺度及精准性，实现多种复杂组织/器官快速仿生组装与功能重建。先后入选国家级青年人才（2021）、中国科学院青年促进创新委员会会员（2019）及广东省级人才（2015）。先后承担多项国家自然基金项目、科技部重点研发计划、中科院及省市级科研项目项，累计经费达2000万元；在生物材料领域发表SCI收录论文50余篇，其中一作或者通讯论文30篇（5篇IF＞15，12篇IF＞10），包括权威期刊：Advanced Functional Materials、Research、Advanced Science及Biomaterials等，累计引用达2000余次；申报中国发明专利30余项，国际PCT专利6项，获发明专利授权15项。

 

个人主页: http://htod.siat.ac.cn/Team/detail.shtml?id=8&cid=11

研究方向:

精准组织工程；生物3D打印；高分子医用材料

主要学术任职:

中国康复医学会修复重建外科专业委员会常务委员、中国医药生物技术协会3D打印分会委员、中国医疗保健国际交流促进会骨科分会委员、中国医学装备协会医用增材制造专业委员会委员、国际华人骨研学会（ICMRS）终身会员及深圳市生物医学工程学会生物医学材料专业委员会副主任委员、担任生物制造领域国际期刊Bio-Design and Manufacturing副主编。

 

学科类别：

生物医学工程; 生物材料

 

承担科研项目情况：

国家自然基金项目；国家重点研发计划；广东省科技基金；深圳市科创委基础布局等。

主要代表论著（通讯或一作，最具代表性 5 篇）:

[1] Huawei Qu, Zhenyu Han, Zhigang Chen, Lan Tang , Chongjian Gao , Kaizheng Liu , Haobo Pan*, Hongya Fu* , Changshun Ruan*, Fractal Design Boosts Extrusion-Based 3D Printing of Bone-Mimicking Radial-Gradient Scaffolds, Research, 2021,2021, 9892689. (A Science Partner Journal)

[2] Yanzhi Liu # , Liuqi Peng #,  Lingli Li , Cuishan Huang , Keda Shi , Xiangbo Meng, Pinpin Wang, Mingming Wu , Ling Li, Huijuan Cao, Kefeng Wu , Qingqiang Zeng, Haobo Pan, William Weijia Lu , Ling Qin *, Changshun Ruan *, Xinluan Wang*.3D-bioprinted BMSC-laden biomimetic multiphasic scaffolds for efficient repair of osteochondral defects in an osteoarthritic rat model, Biomaterials , 2021, 279, 121216.

[3]  Qingfei Liang, Fei Gao, Zhiweng Zeng, Jirong Yang, Mingming Wu, Chongjian Gao, Delin Cheng, Haobo Pan*, Wenguang Liu*, Changshun Ruan*. Coaxial Scale-up Printing of Diameter-tunable Biohybrid Hydrogel Microtubes with High Strength, Perfusability and Endothelialization. Advanced Functional Materials, 2020, 30, 2001485.

[4] Zifeng Lin,  Mingming Wu, Huimin He, Qingfei Liang , Chengshen Hu, Zhiwen Zeng,  Delin Cheng,  Goucheng Wang, Dafu Chen,* Haobo Pan,* and Changshun Ruan *. 3D Printing of Mechanically Stable Calcium-Free Alginate-Based Scaffolds with Tunable Surface Charge to Enable Cell Adhesion and Facile Biofunctionalization, Advanced Functional Materials, 2019, 29(9), 1808439.

 

[5] Fei Gao , Ziyang Xu , Qingfei Liang, Haofei Li, Liuqi Peng , Mingming Wu , Xiaoli Zhao ,  Xu Cui, Changshun Ruan* and Wenguang Liu *. Osteochondral Regeneration with 3D-Printed Biodegradable High-Strength Supramolecular Polymer Reinforced-Gelatin Hydrogel Scaffolds, Advanced Science. 2019, 15(6), 1900867.

 

[6] Fei Gao , Ziyang Xu, Qingfei Liang, Bo Liu , Haofei Li, Yuanhao Wu, Yinyu Zhang,  Zifeng Lin, Mingming Wu, Changshun Ruan*, Wenguang Liu *, Direct 3D Printing of High Strength Biohybrid Gradient Hydrogel Scaffolds for Efficient Repair of Osteochondral Defect, Advanced Functional Materials, 2018, 1706644.

 

[7] Xinyun Zhai , Changshun Ruan*, Yufei Ma , Delin Cheng, Mingming Wu , Wenguang Liu, Xiaoli Zhao, Haobo Pan*, William Weijia Lu *, 3D-bioprinted Osteoblast-laden Nanocomposite Hydrogel Constructs with Induced Microenvironments Promote Cell Viability, Differentiation and Osteogenesis both In Vitro and In Vivo, Advanced Science, 2018, 3:201700550.

 

[8] Moyuan Deng#,*, Jiulin Tan#, Chengshen Hu, Tianyong Hou, Wei Peng, Juan Liu, Bo Yu,Qijie Dai, Jiangling Zhou, Yusheng Yang, Rui Dong, Changshun Ruan*, Shiwu Dong*, Jianzhong Xu*.Modification of PLGA Scaffold by MSC-Derived Extracellular Matrix Combats Macrophage Inflammation to Initiate Bone Regeneration via TGF-β-Induced Protein. Advanced Healthcare Materials, 2020, 9(13):2000353.

 

[9] Huimin He# ,Duo Li#, Zifeng Lin, Liuqi Peng, Jirong Yang, Mingming Wu, Delin Cheng, Haobo Pan and Changshun Ruan*;Temperature-programmable and Enzymatically Solidifiable Gelatinbased Bioinks Enable Facile Extrusion Bioprinting. Biofabrication, 2020,12(4):045003.

 

[10]  Hanhan Xie# , Jundong Shao# ,Yufei Ma# , Jiahong Wang , Hao Wang, Na Yang, Huaiyu Wang , Changshun Ruan*, Yangfeng Luo , Ququan Wang , Paul K. Chu, Xue-feng Yu*, Biodegradable near-infrared photo responsive shape memory implants based on black phosphorus nanofillers, Biomaterials, 2018,164: 11-21.

 

[11] Yufei Ma#, Nan Hu#, Juan Liu#, Xinyun Zhai, Mingming Wu, Chengshen Hu, Long Li, Yuxiao Lai, Haobo Pan, William Weijia Lu, Xinzhou Zhang, Yanfeng Luo,*and Changshun Ruan*, Three-Dimensional Printing of Biodegradable Piperazine-Based Polyurethane-urea Scaffolds with Enhanced Osteogenesis for Bone Regeneration, ACS Appl. Mater. Interfaces, 2019, 11, 9415−9424.  

 

[12] Jinghua Li#, Yun Liu#, Xiaonan Li, Gaofeng Liang, Changshun Ruan* and Kaiyong Cai, ROS self-generation and hypoxia self-enhanced biodegradable magnetic nanotheranostics for targeted tumor therapy. Nanoscale Horizons, 2020 ,5, 350-358.  

 

[13] Zhiwen Zeng, Chengshen Hu, Qingfei Liang, Lan Tang, Delin Cheng, Changshun Ruan*. Coaxial-printed Small-diameter Polyelectrolyte-based Tubes with An Electrostatic Self-assembly of Heparin and YIGSR Peptide for Antithrombogenicity and Endothelialization. Bioactive Materials, 2021, 6: 1628–1638

 

[14] Zhengwei Li, Tianming Du, Changshun Ruan*, Xufeng Niu*. Bioinspired mineralized collagen scaffolds for bone tissue engineering. Bioactive Materials, 2021, 6:1491–1511

 

[15] Juan Liu, Zhigang Chen, Chengshen Hu, Wei Yang, Jinfeng Wang, Weilong Xu, Yuanliang Wang, Changshun Ruan*, Yanfeng Luo*,Fluorescence visualization directly monitors microphase separation behavior of shape memory polyurethanes, Applied Materials Today ,2021,23:100986

 

[16] Cuicui Zhang#, Zhigang Chen #, Juan Liu, Mingming Wu, Jirong Yang, Yaomin Zhu***,William Weijia Lu**, Changshun Ruan*,3D-printed pre-tapped-hole scaffolds facilitate one-step surgery of predictable alveolar bone augmentation and simultaneous dental implantation, Composites Part B, 2022, 229:109461