导师信息
-
王国成
博士
研究员
邮箱 : gc.wang@siat.ac.cn
简介:
博士，博士生导师，中国科学院深圳先进技术研究院研究员。2009 年博士毕业于中国科学院上海硅酸盐研究所，毕业后在澳大利亚悉尼大学和西班牙生物材料研究中心从事交叉学科研究工作。长期致力于人体硬组织替换、软/硬组织再生材料及材料表面纳米工程技术开发应用研究，在生物材料和表/界面领域的主流期刊已发表SCI论文50余篇，其中包括Advanced Materials、Biomaterials、Materials Horizons、Chemical Engineering Journal、Carbon、Applied Materials Today、ACS Applied Materials & Interfaces等，部分研究成果被Nature Materials和PNAS等多个国际顶级期刊文章引用。合作出版专著一本，拥有授权国内发明专利多项。主持多项科技项目，其中包括国家重点研发计划“政府间国际科技创新合作”等重点专项、国家自然科学基金面上项目、广东省自然科学基金和公益能力建设项目、深圳市基础研究、技术攻关、学科布局、国际合作等项目，并作为核心成员参与多项国家重点研发计划项目。
个人主页:
研究方向:
生物材料/组织界面结合问题；硬组织替换和再生生物材料；纳米生物材料；材料表面改性，抗微生物材料
主要学术任职:
Materials 期刊编委；Biofunctional Materials 期刊编委；Frontiers in Materials 期刊的客座编辑；曾任国际期刊BioMed Research International 的Leading Guest Editor；Alliance for Design and Application in Tissue Engineering (ADATE)的顾问团成员；波兰科学基金合作专家（FN-SOP）；中国医促会骨科分会生物材料组委员；中国医促会骨科生物材料学组委员暨骨科分会委员；《Advanced Materials》、《Biomaterials》、《Chemical Engineering Journal》、《Chemical Science》、《ACS Applied Materials and Interface》等多个国际期刊的邀请审稿专家; 《表面技术》杂志评审委员会委员。
学科类别：
材料科学与工程
承担科研项目情况：
2022/01-2025/12：国家自然科学基金委员会-联合基金项目,医用聚醚醚酮表面免疫反应时序调控及其促组织修复研究，参与（第二负责人），在研；
2021/10-2023/09：特异占取S蛋白侵染位点的纳米材料设计及其抗新冠研究，国家重点研发计划项目，主持，在研；
2019/01-2022/12：生物活性陶瓷表面微环境预调制及其对巨噬胞行为和骨再生的影响机制，国自然面上项目，主持，在研；
2018/09-2021/06：生物材料与组织工程制品调控的免疫微环境对组织再生的影响及机制研究，国家重点研发计划，参与，结题；
2018/09-2020/09：骨植入物关键性能优化技术研发，深圳市国际合作项目，主持；
2018/05-2021/05：钛合金表面原位介孔化及生长因子负载的促骨整合作用研究，广东省自然科学基金项目，主持；
2017/07-2020/12：华南生物医用材料与植入器械创新示范基地，国家重点研发计划，子课题单位负责人，结题；
2017/07-2020/07：组织工程骨仿生活化及快速血管化研究，深圳市基础研究学科布局项目，主持，结题；
2017/01-2018/12：新型高骨诱导活性人工关节涂层的研发，广东省省级科技计划项目，主持，结题；
2016/01-2018/01：新型仿生骨材料的关键技术研发，深圳市技术创新计划-技术攻关项目，主持，结题；
2015/10-2017/10：骨科植入体表面化学和微纳拓扑结构的协同调控及其对生物学性能的影响研究，深圳市基础研究项目，主持，结题。
主要代表论著（通讯或一作，最具代表性 5 篇）:
1. Minggang Yang#, Shi Qiu#, Emerson Coy, Shuaijie Li, Karol Załęski, Yao Zhang*, Haobo Pan*, Guocheng Wang*, NIR‐Responsive TiO2 Biometasurfaces: Toward In Situ Photodynamic Antibacterial Therapy for Biomedical Implants. Advanced Materials, 2022, 34(6): 2106314.
2. Guang Zhu#, Guocheng Wang*, Jiao Jiao Li*, Advances in implant surface modifications to improve osseointegration. Materials Advances, 2021: 6901–27
3. Xiaoxia Song#, Fuwei Liu#, Caijie Qiu, Emerson Coy, Hui Liu, Willian Aperador, Karol Załęski, iao Jiao Li, Wen Song, Zufu Lu, Haobo Pan, Liang Kong*, Guocheng Wang*, Nanosurfacing Ti alloy by weak alkalinity-activated solid-state dewetting (AAD) and its biointerfacial enhancement effect, Materials Horizons, 2021,8,912-924.
4. Zhengjiang Xu#, Yan Xia#, Panyu Zhou#, Jiao Jiao Li, Minggang Yang, Yuan Zhang, Yuntong Zhang, Yang Xie, Lu Li, Haobo Pan, Shuogui Xu, Guocheng Wang*, Silicon Incorporation into Hydroxyapatite Nanocarrier Counteracts the Side Effects of Vancomycin for Efficient Chronic Osteomyelitis Treatment, Chemical Engineering Journal, 2021, 406, 126821.
5. Jing Zhao, Danping Lu, Sergio Moya, Haoying Yan, Miaojuan Qiu, Junzong Chen, Xincheng Wang, Yang Li, Haobo Pan, Guochuang Chen*, Guocheng Wang*, Bispecific T-cell engager (BiTE) immunotherapy of ovarian cancer based on MIL-88A MOF/MC gene delivery system, Applied Materials Today, 2020, 20: 100701.
6. Minggang Yang, Hui Liu, Caijie Qiu, Igor Iatsunskyi, Emerson Coy, Sergio Moya, Zhuo Wang, Wenwen Wu, Xiaobing Zhao*, Guocheng Wang*, Electron transfer correlated antibacterial activity of biocompatible graphene Nanosheets-TiO2 coatings, Carbon, 2020, 166, 350-360.
7. Wei Tang#, Yuanman Yu#, Jing Wang, Hui Liu, Haobo Pan, Guocheng Wang*, Changsheng Liu*, Enhancement and orchestration of osteogenesis and angiogenesis by a dual-modular design of growth factors delivery scaffolds and 26SCS decoration, Biomaterials, 2020, 232: 119645.
8. Zhengjiang Xu#, Jing Long#, Ningfeng Zhang#, Huijuan Cao, Wei Tang, Keda Shi, Xinluan Wang, Sergio Moya, Li Duan, Haobo Pan, Yuxiao Lai*, Daping Wang*, Guocheng Wang*, Strong mineralization ability of strontium zinc silicate: Formation of a continuous biomorphic mineralized layer with enhanced osteogenic activity, Colloids Surfaces B Biointerfaces, 2019, 176: 420-430.
9. Zhengjiang Xu, Luis Yate, Yuan Qiu, Willian Aperador, Emerson Coy, Bin Jiang, Sergio Moya, Guocheng Wang*, Haobo Pan, Potential of niobium-based thin films as a protective and osteogenic coating for dental implants: The role of the nonmetal elements, Materials Science and Engineering: C, 2019, 96, 166-175.
10. Xiaoxia Song#, Wei Tang#, Danijela Gregurec, Luis Yate, Sergio Enrique Moya*, Guocheng Wang*, Layered titanates with fibrous nanotopographic features as reservoir for bioactive ions to enhance osteogenesis, Applied Surface Science, 2018, 436, 653-661.
11. Guocheng Wang*, Xiaobing Zhao, Marco Möller, Sergio E. Moya, Interfacial Reaction-Driven Formation of Silica Carbonate Biomorphs with Subcellular Topographical Features and Their Biological Activity, ACS Applied Materials & Interfaces, 2015, 7(42): 23412-23417.
12. Luis Yate, L. Emerson Coy, Danijela Gregurec, Willian Aperador, Sergio E. Moya, Guocheng Wang*, Nb-C nanocomposite films with enhanced biocompatibility and mechanical properties for hard-tissue implant applications, ACS Applied Materials & Interfaces, 2015, 7(11): 6351-6358.
13. Guocheng Wang*, Sergio Moya, ZuFu Lu, Danijela Gregurec, Hala Zreiqat*, Enhancing orthopedic implant bioactivity: Refining the nanotopography, Nanomedicine, 2015, 10(8): 1327-1341.
14. Xiaobing Zhao, Guocheng Wang, Hai Zheng, Zufu Lu, Xia Zhong, Xingbao Cheng, Hala Zreiqat*, Delicate refinement of surface nanotopography by adjusting TiO2 coating chemical composition for enhanced interfacial biocompatibility, ACS Applied Materials & Interfaces, 2013, 5(16): 8203-8209.
15. Wenjie Zhang #, Guocheng Wang#, Yan Liu, Xiaobing Zhao, Duohong Zou, Chao Zhu, Yuqin Jin, Qingfeng Huang, Jian Sun, Xuanyong Liu, Xinquan Jiang*, Hala Zreiqat*, The synergistic effect of hierarchical micro/nano-topography and bioactive ions for enhanced osseointegration, Biomaterials, 2013, 34(13): 3184-3195.
16. Guocheng Wang, Zufu Lu, Xiaobing Zhao, Alexey Kondyurin, Hala Zreiqat*, Ordered HAp nanoarchitecture formed on HAp-TCP bioceramics by “nanocarving” and mineralization deposition and its potential use for guiding cell behaviors, Journal Materials Chemistry B, 2013, 1(19): 2455-2462.
17. Guocheng Wang, Zufu Lu, Xiaobing Zhao, Alexey Kondyurin, Hala Zreiqat*, A facile method to in situ formation of hydroxyapatite single crystal architecture for enhanced osteoblast adhesion, Journal Materials Chemistry B, 2012, 22(36): 19081-19087.
18. Guocheng Wang, Zufu Lu, Dennis Dwarte, Hala Zreiqat*, Porous scaffolds with tailored reactivity modulate in-vitro osteoblast responses, Materials Sciences and Engineering C, 2012, 32(7): 1818-1826.
19. Guocheng Wang, Xuanyong Liu, Hala Zreiqat, Chuanxian Ding, Enhanced effects of nano-scale topography on the bioactivity and osteoblast behaviors of micron rough ZrO2 coatings, Colloids Surfaces B Biointerfaces, 2011, 86(2): 267-274.
20. Guocheng Wang, Zufu Lu, Xuanyong Liu, Xiaming Zhou, Chuanxian Ding, Hala Zreiqat*, Nanostructured glass-ceramic coatings for orthopaedic applications, Journal of the Royal Society Interface. 2011, 8(61): 1192-1203.
21. Guocheng Wang, Fanhao Meng, Chuanxian Ding,Paul K Chu, Xuanyong Liu*, Microstructure, bioactivity and osteoblast behavior of monoclinic zirconia coating with nanostructured surface, Acta Biomaterialia, 2010, 6(3): 990-1000.
22. Guocheng Wang, Hala Zreiqat*, Functional coatings or films for hard-tissue applications, Materials (Basel). 2010, 3(7): 3994-4050.
23. Guocheng Wang, Xuanyong Liu*, Jianhua Gao, Chuanxian Ding, In vitro bioactivity and phase stability of plasma-sprayed nanostructured 3Y-TZP coatings, Acta Biomaterilia, 2009, 5(6): 2270-2278.